Oct. 8, 2021

CCR5 | Investigating myself

CCR5 | Investigating myself

Episode 373. Investigating myself. Topic: CCR5. How does HIV immunity work? Do I have deletions in my CCR5 gene? How can I find this out?

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Methodology notes:
I searched the hg38 BAM file at chr3:46373450-46373488 (samtools view) for the deletion of GTCAGTATCAATTCTGGAAGAATTTCCAGACA. Reads contained the full sequence. I included a search for sequences with concatenated flanking nucleotides (indicating the deletion) but did not find any. I also searched unmapped reads. This strongly indicated that I am homozygous for the intact CCR5.